Home > Research Studies > Neuroimaging and Cognition in Rolandic Epilepsy (CREME)

Cognition in children with active and remitted Rolandic Epilepsy and potential neuro-developmental measures derived from MRI and EEG (CREME).

Why it matters

Impairments of speech, reading and general clumsiness can be seen in children with Rolandic epilepsy. These problems could be an indication of significant global brain changes. However, routine brain imaging is usually normal. This would suggest that any changes are hard to identify. To explore subtle changes requires a detailed investigation of brain structure. If changes are identified, this could improve our understanding of why cognitive problems occur in this condition. This could potentially lead to new treatments and therapies for children with Rolandic epilepsy.

What we are doing

Neuroimaging and neuropsychological methods will be used to investigate the structure and function of brains in children with Rolandic epilepsy. The information will be compared to brains in healthy children. This will be repeated once their seizures have stopped.

We aim to investigate:

  • What changes occur in brain thickness and how these relate to the quality of connecting pathways
  • How different brain regions with altered thickness interact with each other
  • How much do brain differences relate to neuro-psychological impairments

Who is conducting the research?

Mr. Stuart Smith, Dr. Anna Smith and Professor Deb Pal at King’s College London.

Who has reviewed this study?

The study is supported by Epilepsy Research UK and the Waterloo Foundation. It has received ethical approval from the Camberwell Research Ethics Committee.


If you would like to find out more, please contact Stuart Smith by email at stuart.smith@kcl.ac.uk

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