Home > Publications > Reply to: Is a microRNA-328 binding site in PAX6 associated with Rolandic epilepsy?

We thank McGlade et al. for their interest in our recent publication,1 where we identify an association between a PAX6 30 UTR variant rs662702 – whose T allele disrupts the seed region of microRNA-3282,3 – and EEG centrotemporal spikes (CTS) in Rolandic Epilepsy (RE). In their letter to the editor4 they question the evidence for association with RE [sic], they conjecture that the association is due to inadequately accounted for multiple hypothesis testing and population stratification, and they present data from both public control populations and their own case study. While the control data demonstrate the importance of case–control matching as highlighted in Panjwani et al., their case data provide additional evidence supporting our original conclusion.

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